NES — Nestin
NES belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NES's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Junction Identity Endothelial cell development | ADGRF5, AKAP13, CDH5, CXCL12, DENND5A, FGF12, FURIN, HSPA12B +13 more | View in SCUBA |
| Glial cells | RNA Splicing Processing RNA processing & translation | DDX3X, DDX5, HNRNPA2B1, HNRNPAB, HNRNPDL, HNRNPH1, MAFB, RND3 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ21841 |
|---|---|
| Chromosome | 1: 156668763-156677407 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Neurogenesis |
Function
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen- stimulated proliferation of neural progenitor cells (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.