MAFB — MAF bZIP transcription factor B
MAFB belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAFB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more | View in SCUBA |
| Fibroblasts | Hypoxia-driven EMT Stress | ARC, CITED2, CSKMT, DDIT4, FAM43A, FAM53C, HBEGF, HEXIM1 +7 more | View in SCUBA |
| Glial cells | RNA Splicing Processing RNA processing & translation | DDX3X, DDX5, HNRNPA2B1, HNRNPAB, HNRNPDL, HNRNPH1, NES, RND3 +2 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Response DNA/chromatin regulation | BRD2, BTG2, CITED2, H2AX, HBEGF, HEXIM1, INTS6, NR4A1 +7 more | View in SCUBA |
| Macrophages | Early response genes Inflammatory | ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more | View in SCUBA |
| Smooth muscle cells | Translation initiation/RNA-binding RNA processing & translation | BRI3, CDV3, EIF5, EPC1, FAM133B, FAM53C, FUS, PPP1R10 +2 more | View in SCUBA |
About the gene
| Synonyms | KRML |
|---|---|
| Chromosome | 20: 40685848-40689236 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid- specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.