NSUN6 — NOP2/Sun RNA methyltransferase 6
NSUN6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSUN6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, PMAIP1, RBBP8 +6 more | View in SCUBA |
| Innate lymphoid cells | NK Cytokine Signaling Immune regulation | BORCS7, C6orf62, DDX18, IER3, LMO4, MAT2A, PGGHG, PLCG2 +3 more | View in SCUBA |
| Macrophages | NF-κB Activation Inflammatory | BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more | View in SCUBA |
About the gene
| Synonyms | ARL5B-AS1, FLJ23743, NOPD1 |
|---|---|
| Chromosome | 10: 18545561-18659285 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Methyltransferase, RNA-binding, Transferase |
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.