NK Cytokine Signaling
Gene co-expression module in Innate lymphoid cells
| Category | Immune regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
PLCG2 is a central signaling enzyme in NK cell and B cell receptor activation, generating DAG and IP3. SOCS1 is a JAK-STAT feedback inhibitor induced by cytokine signaling. IER3 is an immediate-early gene with NF-κB regulatory roles. MAT2A produces S-adenosylmethionine, linking to methylation and metabolic reprogramming. NSUN6 is an RNA methyltransferase. DDX18 is an RNA helicase. The combination of PLCG2 (NK activation signal) and SOCS1 (feedback inhibition) with IER3 suggests cytokine/activation signaling with regulatory feedback, relevant to NK cell inflammatory activation.
Genes
BORCS7, C6orf62, DDX18, IER3, LMO4, MAT2A, NSUN6, PGGHG, PLCG2, RSRC2, SOCS1, SUGT1
Most correlated modules
- Transcriptional Activation · correlation 0.90
- ILC3 Transcriptional Identity · correlation 0.89
- RNA Chromatin Regulation · correlation 0.88
- Immediate Early Response · correlation 0.86
- Dissociation Stress Response · correlation 0.85
- Heat Shock Response · correlation 0.85
- Cytokine-driven Activation · correlation 0.85
- Integrated Stress Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.