IER3 — Immediate early response 3

IER3 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IER3's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4 +9 more	View in SCUBA
Endothelial	NF-κB Activation Inflammation	C2CD4B, HSPA6, ICAM5, MAP3K8, NFKBIA, NFKBID, PMAIP1, PTGS2 +5 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more
Goblet cells	NF-κB Stress Response Stress	ATF3, CCNL1, EGR3, MAFF, MYADM, NFKBIA, NR4A1, RHOB +1 more	View in SCUBA
Innate lymphoid cells	NK Cytokine Signaling Immune regulation	BORCS7, C6orf62, DDX18, LMO4, MAT2A, NSUN6, PGGHG, PLCG2 +3 more	View in SCUBA
Lymphatic endothelial	Hypoxic Stress Response Stress	CCL2, CHMP1B, ID2, IFRD1, RRAD, SOX4, VEGFA	View in SCUBA
Macrophages	NF-κB Inflammatory Activation Inflammatory	ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more	View in SCUBA
Monocytes	NF-κB Signaling Inflammatory	BIRC3, ERN1, G0S2, ICAM1, IRAK2, NFKB1, PDE4B, PNRC1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	TCR-Induced Early Response TCR Signaling	ATF3, EGR1, GLA, HMGCS1, NR4A1, NUP58, PPP1R15B, RHOB +3 more
Neutrophils	Inflammasome IL-1 Response Cytokine & chemokine secretion	CSRNP1, EGR3, G0S2, IFRD1, IL1B, IL1RN, IVNS1ABP, LPCAT1 +5 more
Smooth muscle cells	NF-kB Stress Response Stress	BHLHE40, CCNL1, FADS3, HSP90AB1, MIDN, NFKBIZ, PPP1R15A, THBS1 +1 more	View in SCUBA

About the gene

Synonyms	DIF-2, IEX-1, IEX-1L, PRG1
Chromosome	6: 30743199-30744548
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins

Function

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.