PLCG2 — Phospholipase C gamma 2
PLCG2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLCG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing RNA processing | ANKRD11, ARGLU1, CYBC1, LUC7L3, PNN, SON, SRRM2, TCIRG1 +1 more | View in SCUBA |
| Fibroblasts | Hypoxia-driven EMT Stress | ARC, CITED2, CSKMT, DDIT4, FAM43A, FAM53C, HBEGF, HEXIM1 +7 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1 +20 more | |
| Innate lymphoid cells | NK Cytokine Signaling Immune regulation | BORCS7, C6orf62, DDX18, IER3, LMO4, MAT2A, NSUN6, PGGHG +3 more | View in SCUBA |
About the gene
| Chromosome | 16: 81779279-81962685 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase, Transducer |
| Biological process | Lipid degradation, Lipid metabolism |
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.