TMEM100 — Transmembrane protein 100
TMEM100 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM100's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR +19 more | View in SCUBA |
| Pericytes | Arterial Pericyte Identity Developmental | ATP13A3, BMX, FBLN2, GJA5, KCTD12, LTC4S, PLLP, SEMA3G +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ10970, FLJ37856 |
|---|---|
| Chromosome | 17: 55719627-55732121 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein |
| Biological process | Differentiation |
Function
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.