PTGES — Prostaglandin E synthase
PTGES belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGES's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, LXN, MT2A +5 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDH23, CDKN1C, CHST7, CKB, CYFIP2, KNDC1, LYPD2 +6 more | View in SCUBA |
About the gene
| Synonyms | MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12 |
|---|---|
| Chromosome | 9: 129738331-129753042 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Isomerase, Oxidoreductase, Transferase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Function
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione- dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.