PYGL — Glycogen phosphorylase L
PYGL belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PYGL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | ENS Developmental TFs Development | ERBIN, FRMD3, HAND2, LRRC4C, MAP4K4, SEC11C, SLC25A36, TBX3 +2 more | View in SCUBA |
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1 +7 more | View in SCUBA |
| Neutrophils | Degranulation Trafficking Degranulation | ATP11A, BIN2, CSGALNACT2, FRY, KDM7A, LPGAT1, RAB27A, RIN3 +7 more |
About the gene
| Synonyms | GSD6 |
|---|---|
| Chromosome | 14: 50857891-50944483 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Glycosyltransferase, Transferase |
| Biological process | Carbohydrate metabolism, Glycogen metabolism |
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.