TBX3 — T-box transcription factor 3
TBX3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Membrane Transport Endothelial cell development | AQP1, CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, OSTF1 +9 more | View in SCUBA |
| Enterocytes | Brush border lipid handling Absorption | ABCG1, ABHD12, ARL14, CDHR2, ENTPD8, IDS, PNPLA2, RAI14 +2 more | View in SCUBA |
| Fibroblasts | Telocyte Identity Program Developmental | ADGRL3, ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, LAMA4, PDIA5 +10 more | View in SCUBA |
| Glial cells | ENS Developmental TFs Development | ERBIN, FRMD3, HAND2, LRRC4C, MAP4K4, PYGL, SEC11C, SLC25A36 +2 more | View in SCUBA |
About the gene
| Synonyms | TBX3-ISO, UMS, XHL |
|---|---|
| Chromosome | 12: 114670255-114684175 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'- TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.