RHOG — Ras homolog family member G
RHOG belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHOG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH +22 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 more | View in SCUBA |
| Neutrophils | Neutrophil Motility Cytoskeleton Migration & adhesion | CDKN2D, CNN2, COTL1, CST7, GLIPR1, GMFG, GNB2, GPSM3 +9 more |
About the gene
| Synonyms | ARHG, MGC125835, MGC125836 |
|---|---|
| Chromosome | 11: 3826978-3840959 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells. (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.