RNASE6 — Ribonuclease A family member k6
RNASE6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASE6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Myeloid Innate Immune Myeloid development | CCR2, CUX2, CYBB, FXYD7, KCNC3, KIF17, NFKB1, PLD4 +5 more | |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Innate immunity | AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, IL13RA1, LDHB +7 more | View in SCUBA |
About the gene
| Synonyms | RAD1, RNaseK6, RNS6 |
|---|---|
| Chromosome | 14: 20781268-20782467 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease |
Function
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram- negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.