SCN7A — Sodium voltage-gated channel alpha subunit 7
SCN7A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCN7A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Submucosal Fibroblast Developmental | ADAMTS19, ANGPTL7, C7, CHRDL1, DPT, GDF6, GPNMB, HAND2 +9 more | View in SCUBA |
| Glial cells | Glial Adhesion Cytoskeletal migration & adhesion | AKAP9, COL21A1, DOCK5, EPB41L2, KIAA1217, LTBP3, NCAM1, RALGPS2 +1 more | View in SCUBA |
About the gene
| Synonyms | NaG, Nav2.1, Nav2.2, SCN6A |
|---|---|
| Chromosome | 2: 166403573-166611482 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.