SIT1 — Signaling threshold regulating transmembrane adaptor 1
SIT1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ACP5, B2M, CALCOCO1, CCNG2, CHST11, CORO1A, HLA-A, IL32 +10 more | View in SCUBA |
| Gamma-delta T cells | T Cell Survival T cell maturation | CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5 +13 more | |
| Mucosal-associated invariant T cell | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, COA4, DBP, DENND2D +15 more |
About the gene
| Synonyms | SIT |
|---|---|
| Chromosome | 9: 35649295-35650931 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.