CALHM2 — Calcium homeostasis modulator family member 2
CALHM2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CALHM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Tissue-resident memory B B cell maturation | CCR1, CMTM7, FCRL4, FGD4, GSN, ITGB7, PIK3R6, PLD4 +4 more | View in SCUBA |
| Gamma-delta T cells | T Cell Homeostasis Housekeeping | ATP6V0E1, CNPY2, CSK, CSTB, DAD1, FERMT3, GTF2H5, MYL12A +11 more | |
| Monocytes | Mitochondrial Immune Regulation Mitochondrial & OxPhos | CORO1B, DNASE2, DOK2, NDUFAF3, SIGLEC10, SLC39A1, UCP2 | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFRP1, ARL2, ATP6V0E1, CCS, COA4, DBP, DENND2D, DMAC1 +15 more | |
| Smooth muscle cells | Vascular Matrix Secretion ECM remodeling | ARPC1B, BGN, HSPB7, MGP, MXI1, RAB13, TRIM47 | View in SCUBA |
About the gene
| Synonyms | FAM26B |
|---|---|
| Chromosome | 10: 103446786-103452402 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Ion channel |
| Biological process | Ion transport, Transport |
Function
Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.