STXBP1 — Syntaxin binding protein 1
STXBP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STXBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ABI3, CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, HDAC7, ITGA6 +8 more | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL +7 more | View in SCUBA |
About the gene
| Synonyms | hUNC18, MUNC18-1, nSec1, rbSec1, UNC18 |
|---|---|
| Chromosome | 9: 127579370-127696027 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.