TARBP1 — TAR (HIV-1) RNA binding protein 1
TARBP1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TARBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9 +27 more | View in SCUBA |
About the gene
| Synonyms | TRM3, TRMT3, TRP-185 |
|---|---|
| Chromosome | 1: 234391313-234479179 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Methyltransferase, RNA-binding, Transferase, tRNA-binding |
| Biological process | tRNA processing |
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs. (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.