THEM4 — Thioesterase superfamily member 4
THEM4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
THEM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling activation TCR/AP1/NFKb pathway | CNST, CORO1B, DAPP1, ECI1, FAAH2, FCMR, GPCPD1, KLHL24 +8 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ADRB2, ANTXR2, C1orf162, KLRG1, NSG1, RASSF3, RIPOR2, S1PR1 +7 more | |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ARL14EP, ATP2A3, BIN1, BTN3A2, DGKZ, OSTC +8 more |
About the gene
| Synonyms | CTMP |
|---|---|
| Chromosome | 1: 151870866-151909637 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Apoptosis, Fatty acid metabolism, Lipid metabolism |
Function
Has acyl-CoA thioesterase activity towards medium and long- chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to, inhibits AKT1 phosphorylation and activity. According to, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.