DGKZ — Diacylglycerol kinase zeta
DGKZ belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DGKZ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, BIN1, CD37, DGKA, EIF3F, EIF3L, EIF4B, GYPC +22 more | View in SCUBA |
| Gamma-delta T cells | T-bet Effector Differentiation T cell maturation | ABHD17A, BCL7C, CAPNS1, CHST12, EFHD2, FMNL1, GNAI2, GNB2 +15 more | |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ARL14EP, ATP2A3, BIN1, BTN3A2, OSTC, PTP4A2 +8 more | |
| Natural Killer cells | Cytoskeletal Remodeling Cytoskeleton & motility | ADD3, ARHGAP25, ARHGEF3, C1orf21, CAPN2, CYTH1, DIP2A, GBP5 +4 more | View in SCUBA |
About the gene
| Synonyms | DAGK5, DAGK6, DGK-ZETA, hDGKzeta |
|---|---|
| Chromosome | 11: 46332905-46380554 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Lipid metabolism |
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Regulates RASGRP1 activity. Does not regulate RASGRP1 activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.