TSPAN18 — Tetraspanin 18
TSPAN18 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSPAN18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T quiescence T cell development | CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, NOSIP +6 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4 +10 more | View in SCUBA |
| Pericytes | Vascular Tone Homeostasis Housekeeping | ACSL5, AQP1, AQP3, ASS1, DCHS1, GIT1, NPR1, RUNDC3B +1 more | View in SCUBA |
About the gene
| Synonyms | TSPAN |
|---|---|
| Chromosome | 11: 44726465-44932423 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.