VBP1 — VHL binding protein 1
VBP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | mRNA Splicing RNA processing & translation | DIAPH1, EIF4A3, FUBP1, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1 +8 more | View in SCUBA |
| Innate lymphoid cells | mTOR Metabolic Stress Stress | ADPGK, AKR1A1, ATP5IF1, BAX, CPNE1, GLO1, GSTO1, HNRNPR +9 more | View in SCUBA |
About the gene
| Synonyms | PFD3, PFDN3 |
|---|---|
| Chromosome | X: 155197007-155239841 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.