mRNA Splicing
Gene co-expression module in Endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
The top hub genes are HNRNPA3, HNRNPD, HNRNPA2B1 — all heterogeneous nuclear ribonucleoproteins involved in pre-mRNA processing and mRNA stability. SRSF10 and SRSF2 are serine/arginine-rich splicing factors. FUBP1 is an RNA/DNA binding protein. KHDRBS1 (Sam68) is an RNA-binding protein. MAGOH is part of the exon junction complex. EIF4A3 is an RNA helicase in the EJC. SFPQ is a splicing/transcription factor. NOP56 is a snoRNP component. NUDCD2 is a co-chaperone. SUZ12 is a PRC2 component. PTGES3 is a co-chaperone/prostaglandin synthase. VBP1 is a prefoldin subunit. GLRX5 is a glutaredoxin. DIAPH1 is a formin. The module is strongly enriched for hnRNP/SR splicing factors and RNA processing components. Mild upregulation in inflammation. Neighbor context: adjacent to other RNA-processing and nuclear transport modules, consistent with a general RNA splicing program.
Genes
DIAPH1, EIF4A3, FUBP1, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1, MAGOH, NOP56, NUDCD2, PTGES3, SFPQ, SRSF10, SRSF2, SUZ12, VBP1
Most correlated modules
- Spliceosome snRNP Assembly · correlation 0.87
- Nuclear Transport · correlation 0.84
- Nuclear Transport · correlation 0.81
- DNA Damage Repair · correlation 0.76
- Stress RNA Processing · correlation 0.74
- DNA Replication · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.