WHAMM — WASP homolog associated with actin, golgi membranes and microtubules
WHAMM belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WHAMM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | AEBP2, ARID1B, ATG12, ATXN2L, BRWD1, CSNK1G3, EHBP1L1, FBRS +18 more | |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Processing Stress RNA processing & translation | DDX3X, ETV3, HSPA5, IVNS1ABP, KDM2A, NAF1, RALGAPA1, SFPQ +3 more |
About the gene
| Synonyms | KIAA1971, WHAMM1, WHDC1 |
|---|---|
| Chromosome | 15: 82809628-82836108 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.