TXNL4A — Thioredoxin like 4A
TXNL4A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TXNL4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1D, ATP5ME, COX6A1, COX6B1, COX6C, DNAJC8, NDUFA11, NDUFA4 +6 more | View in SCUBA |
| Endothelial | mRNA Splicing Stress RNA processing & translation | CCDC50, CCT6A, FAM114A1, GLRX3, PPM1G, RTRAF, SRSF9, YWHAE | View in SCUBA |
| Gamma-delta T cells | T-bet Effector Differentiation T cell maturation | ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2 +15 more | |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Synonyms | DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD |
|---|---|
| Chromosome | 18: 79970813-80033949 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis, mRNA processing, mRNA splicing |
Function
Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.