RTRAF — RNA transcription, translation and transport factor
RTRAF belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RTRAF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1D, ATP5ME, COX6A1, COX6B1, COX6C, DNAJC8, NDUFA11, NDUFA4 +6 more | View in SCUBA |
| CD4⁺ T cells | OxPhos & proteasome Mitochondrial & OxPhos | CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM +10 more | View in SCUBA |
| Endothelial | mRNA Splicing Stress RNA processing & translation | CCDC50, CCT6A, FAM114A1, GLRX3, PPM1G, SRSF9, TXNL4A, YWHAE | View in SCUBA |
| Gamma-delta T cells | RNA Processing RNA processing & translation | ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, BUD23, CIAO2B, E2F4, ELAVL1 +12 more | |
| Glial cells | Proteostasis Stress Response Stress | ATOX1, ATP5MG, ATP6V0E1, C19orf53, C4orf3, COX7B, CYSTM1, GUK1 +7 more | View in SCUBA |
| Goblet cells | Actin Dynamics Cytoskeletal | ABRACL, CD24, CFL1, MYL12A, NDUFB4, NDUFS5, OCIAD2, PIN4 +3 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
About the gene
| Synonyms | C14orf166, CGI-99, CLE, CLE7, hCLE1, LCRP369, RLLM1 |
|---|---|
| Chromosome | 14: 51989514-52010694 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.