SLIRP — SRA stem-loop interacting RNA binding protein
SLIRP belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLIRP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitochondrial Translation Mitochondrial & OxPhos | BOLA3, MRPL20, MRPL36, MRPS34, PDCD5, POLR2I, PSMA3, PSMB5 +2 more | View in SCUBA |
| CD4⁺ T cells | Proteasome/translation Protein processing & ER | ANP32E, CDC123, EIF4E, EIF5B, EMC8, MRPL20, NME7, PDXK +9 more | View in SCUBA |
| Endothelial | Mitochondrial OxPhos Mitochondrial & OxPhos | ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, PFN1, POLR2E +3 more | View in SCUBA |
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2 +18 more | |
| Goblet cells | Glutathione Detoxification Stress | EIF3K, GSTP1, HINT1, HMGA1, MGST1, MGST3, SNRPD2, TST +1 more | View in SCUBA |
| Macrophages | ATP Synthase Complex Mitochondrial & OxPhos | ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, LSM6 +14 more | View in SCUBA |
About the gene
| Synonyms | C14orf156, DC50 |
|---|---|
| Chromosome | 14: 77708071-77761104 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor, RNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.