POLR2I — RNA polymerase II subunit I
POLR2I belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLR2I's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitochondrial Translation Mitochondrial & OxPhos | BOLA3, MRPL20, MRPL36, MRPS34, PDCD5, PSMA3, PSMB5, RPL26L1 +2 more | View in SCUBA |
| CD8⁺ T cells | RNA & Redox Housekeeping RNA processing & translation | ANP32A, C11orf58, CCT6A, COPRS, DPM2, GGCT, GLRX3, LAGE3 +3 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH +22 more | View in SCUBA |
About the gene
| Synonyms | hRPB14.5, RPB9 |
|---|---|
| Chromosome | 19: 36113709-36115213 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins |
| Biological process | Transcription |
Function
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2I/RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.