TIMM10 — Translocase of inner mitochondrial membrane 10
TIMM10 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIMM10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitochondrial Translation Mitochondrial & OxPhos | BOLA3, MRPL20, MRPL36, MRPS34, PDCD5, POLR2I, PSMA3, PSMB5 +2 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | ALYREF, BANF1, CNIH4, COX8A, HAUS1, HMGN1, ILF2, LSM5 +8 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 more | View in SCUBA |
About the gene
| Synonyms | TIM10, TIM10A, TIMM10A |
|---|---|
| Chromosome | 11: 57528464-57530803 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Protein transport, Translocation, Transport |
Function
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.