B-cell antigen presentation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Strong B-cell identity module: MS4A1 (CD20), CIITA (MHC-II master regulator), CD-associated TBC1D10C, STAT6 (B-cell IL4 signaling), TMC6/TMC8, EVL, APBB1IP, CYTH4, HHEX. The presence of MS4A1 (CD20) and CIITA along with antigen-presentation/B-cell signaling genes marks a mature B-cell antigen-presentation/identity program. Disease-associated (sig inflammation).
Genes
APBB1IP, BMP2K, BTN2A2, CIITA, CYTH4, EVL, HHEX, MS4A1, SLC35D2, STAT6, SYTL1, TBC1D10C, TMC6, TMC8, YPEL3
Most correlated modules
- Lymphoid signaling regulators · correlation 0.88
- B-cell activation · correlation 0.81
- B-cell signaling regulators · correlation 0.80
- Chromatin & genome maintenance · correlation 0.76
- B cell activation signaling · correlation 0.74
- Chromatin modifiers · correlation 0.71
- mRNA splicing · correlation 0.70
- Atypical memory B cell · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.