mRNA splicing
Gene co-expression module in CD19⁺ B cells
| Category | RNA processing |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Top hubs are splicing/nuclear speckle factors: ARGLU1, PNN, SRRM2, SON, LUC7L3 — all core mRNA splicing and speckle components. The module clearly represents an RNA splicing/processing program. Peripheral genes (TCIRG1, CYBC1, VMP1, PLCG2) are minor and not in the core splicing theme.
Genes
ANKRD11, ARGLU1, CYBC1, LUC7L3, PLCG2, PNN, SON, SRRM2, TCIRG1, VMP1
Most correlated modules
- Chromatin modifiers · correlation 0.89
- Chromatin & genome maintenance · correlation 0.85
- B-cell signaling regulators · correlation 0.81
- Lymphoid signaling regulators · correlation 0.77
- B-cell signaling regulators · correlation 0.77
- B-cell activation · correlation 0.71
- B Cell Identity Signaling · correlation 0.71
- B-cell antigen presentation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.