Chromatin modifiers
Gene co-expression module in CD19⁺ B cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by chromatin modifiers and transcriptional regulators: KMT2C (H3K4 methyltransferase), KDM5A (H3K4 demethylase), NCOA3 (coactivator), NFAT5, plus RNA regulators SMG1 (NMD kinase), MBNL1, RBM5, and BIRC6. The module is coherent and uniform, reflecting a broad nuclear gene-regulation program centered on chromatin/transcription. DNA/chromatin regulation is the best fit given the histone-modifying hubs.
Genes
ATP2A3, BIRC6, KDM5A, KMT2C, LPIN1, MBNL1, NCOA3, NFAT5, RBM5, SMG1
Most correlated modules
- B-cell signaling regulators · correlation 0.90
- Chromatin & genome maintenance · correlation 0.90
- mRNA splicing · correlation 0.89
- B-cell signaling regulators · correlation 0.86
- B Cell Identity Signaling · correlation 0.85
- BCR Signaling Regulation · correlation 0.83
- Leukocyte Migration Signaling · correlation 0.79
- Chromatin Modification · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.