B-cell signaling regulators
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are largely ubiquitous regulatory/signaling factors: SCAF11 (splicing), MYCBP2 (ubiquitin ligase), PRRC2C, ATF7IP (chromatin), DNAJB14, GOLGA4/TGOLN2 (Golgi). However the module also carries clear B/lymphoid regulators: INPP5D (SHIP1), IKZF3 (Aiolos), AKNA, PDE7A. The mixture of housekeeping signaling/trafficking with lymphoid transcription factors and uniform low-moderate expression suggests a broadly co-expressed B-cell signaling/regulation program rather than a single pathway. The most specific concordant signal is B-cell signaling regulators.
Genes
AKNA, ATF7IP, DNAJB14, FCHSD2, GOLGA4, IKZF3, INPP5D, MYCBP2, PDE7A, PRRC2C, SCAF11, TGOLN2
Most correlated modules
- Chromatin modifiers · correlation 0.90
- Chromatin & genome maintenance · correlation 0.89
- Leukocyte Migration Signaling · correlation 0.85
- Lymphoid signaling regulators · correlation 0.84
- Chromatin Modification · correlation 0.83
- BCR Signaling Regulation · correlation 0.83
- B-cell activation · correlation 0.82
- mRNA splicing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.