Immediate Early NFkB
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Immediate-early/AP-1 and NF-kB response: DUSP2, IER2, EGR1, EGR3, CSRNP1, ZFP36, NFKBIA, SQSTM1, CDKN1A, PPP1R15A/B. Strongly resembles M44 activation program — neighbor consistency supports immediate early gene/NFkB module.
Genes
ARL5B, CDKN1A, CSRNP1, DUSP2, EGR1, EGR3, IER2, NFKBIA, PPP1R15B, SQSTM1, TMEM88, ZFP36
Most correlated modules
- AP-1 Immediate Early · correlation 0.88
- Early Response Stress · correlation 0.85
- Integrated Stress Response · correlation 0.82
- ATF4 Stress Response · correlation 0.79
- Immediate early response · correlation 0.73
- Heat Shock Response · correlation 0.69
- NF-kB activation/survival · correlation 0.69
- B cell quiescence · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.