NR4A2 — Nuclear receptor subfamily 4 group A member 2

NR4A2 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NR4A2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Early Response Stress Stress	ANKRD37, DNAJA1, GTF2B, SAT1, SIK1, SOCS3, UBB, UBC	View in SCUBA
CD4⁺ T cells	Immediate early activation TCR/AP1/NFKb pathway	ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, PABPC1 +18 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	BTG2, CD69, EGR1, FOS, FOSB, IER2, JUNB, LEPROTL1 +5 more	View in SCUBA
Fibroblasts	Inflammatory TF Response Inflammatory	ADAMTS4, CEBPD, CMIP, FOSL2, KLF9, MAT2A, NR4A1, NR4A3 +2 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more
Innate lymphoid cells	NR4A Activation Response activation	ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more	View in SCUBA
Lymphatic endothelial	DNA Damage Response DNA/chromatin regulation	BRD2, BTG2, CITED2, H2AX, HBEGF, HEXIM1, INTS6, MAFB +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	NR4A Immediate-Early Inflammatory	ANKRD37, CHMP1B, CKS2, CYCS, EIF4A3, ETV3, GLA, NR4A1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Negative Feedback Immune regulation	ARL4A, BCAS2, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIA +7 more
Natural Killer cells	NK Activation Response activation	CREM, EIF1, FTH1, MAFF, SELENOK, SRGN, ZNF331	View in SCUBA
Smooth muscle cells	NR4A-ADAMTS Activation Stress	ADAMTS1, ADAMTS4, ADAMTS9, AVPR1A, DUSP8, HIPK2, KLF9, MYC +5 more	View in SCUBA

About the gene

Synonyms	HZF-3, NOT, NURR1, RNR1, TINUR
Chromosome	2: 156324437-156342348
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation

Function

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.