Activation/Migration
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes RGS1, RGS2, GPR183 (EBI2), GPR65, KLF6, DUSP8, DUSP10, TNFSF9, MCL1, MARCKS, NR1D2 form a classic immediate-early/activation and migration program. RGS1/RGS2 regulate GPCR signaling and B-cell positioning; GPR183 and GPR65 govern follicular/germinal center localization; DUSPs and KLF6 are immediate-early response genes; TNFSF9 (4-1BBL) is activation. This is an AP1/NFkB-like activation and GPCR-mediated migration state.
Genes
AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, IDS, KLF6, LDLRAD4, MARCKS, MCL1, NR1D2, PIGT, RGCC, RGS1, RGS2, RILPL2, SBDS, SNN, TNFSF9
Most correlated modules
- TNF/NF-kB response · correlation 0.81
- NF-kB signaling · correlation 0.78
- Early Response Stress · correlation 0.77
- NF-kB activation/survival · correlation 0.76
- B cell activation · correlation 0.76
- Chromatin Modification · correlation 0.74
- B-cell Maturation · correlation 0.72
- MHC-I Antigen Presentation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.