GTF2B — General transcription factor IIB
GTF2B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Early Response Stress Stress | ANKRD37, DNAJA1, NR4A2, SAT1, SIK1, SOCS3, UBB, UBC | View in SCUBA |
| CD4⁺ T cells | Integrated Stress Response Stress | CYCS, DDIT3, EIF1, EIF4A3, IFRD1, NASP, PTMA, TUBA1A | View in SCUBA |
| Innate lymphoid cells | Transcriptional Activation DNA regulation & transcription | AKIRIN1, CHORDC1, FAM133B, FAM53C, GOLGB1, IDI1, MORF4L2, NABP1 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Stress UPR Stress | DDIT3, DNAJB9, EIF4A1, HERPUD1, HNRNPA0, IDI1, LDHA, MAP1LC3B +9 more | |
| Natural Killer cells | TGF-beta Repression DNA regulation & transcription | BZW1, HBP1, ODC1, POLR2K, SKIL, SKP1, SPTY2D1, UBE2D3 | View in SCUBA |
About the gene
| Synonyms | TFIIB |
|---|---|
| Chromosome | 1: 88852633-88891944 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Acyltransferase, DNA-binding, Transferase |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP- independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.