TSC22D2 — TSC22 domain family member 2
TSC22D2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSC22D2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Antiviral Restriction Anti-viral | FCRL1, GLS, PPM1K, SP100, SP140L, STAT3, TGFB1, WSB1 +1 more | View in SCUBA |
| CD4⁺ T cells | Unfolded Protein Response Protein processing & ER | ARF4, ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3 +7 more | View in SCUBA |
| Gamma-delta T cells | Circadian Clock DNA/chromatin regulation | BHLHE40, CDK17, CPEB2, CRY1, IRF1, ITPRIP, MEF2D, NR1D2 +5 more | |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Processing Stress RNA processing & translation | DDX3X, ETV3, HSPA5, IVNS1ABP, KDM2A, NAF1, RALGAPA1, SFPQ +3 more |
About the gene
| Synonyms | KIAA0669, TILZ4a, TILZ4b, TILZ4c |
|---|---|
| Chromosome | 3: 150408298-150466422 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
Function
Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.