MHC-II antigen presentation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
Dominated by MHC class II genes (HLA-DPA1, HLA-DPB1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DRA) plus the invariant chain CD74, antigen processing components (CTSS, TAPBP), and B-cell markers (CD79A). This is a clear MHC-II antigen presentation program intrinsic to B cells, which are professional antigen-presenting cells. High expression and detection, core coherence. CYBA, IL2RG, ICAM3, CD52 are also immune accessory genes.
Genes
ARID5A, CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ICAM3, IL2RG, RAB29, TAPBP, TMBIM4, TNFRSF14
Most correlated modules
- MHC-I Antigen Presentation · correlation 0.78
- Membrane adhesion remodeling · correlation 0.75
- B cell activation signaling · correlation 0.72
- TGF-beta/differentiation · correlation 0.70
- B-cell antigen presentation · correlation 0.67
- Antiviral Restriction · correlation 0.66
- NFkB/MAPK activation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.