mRNA Splicing
Gene co-expression module in CD19⁺ B cells
| Category | RNA processing |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
Dominated by splicing/RNA-processing factors: CCNL1, RSRP1, PCF11, DDX5, EIF4A2, CLK1, NUFIP2, RBM39, SRSF5, DDX3X, AFF4, TAF1D. CLK1 and SRSF5 control splicing; PCF11 is 3' cleavage; CCNL1 regulates transcription/splicing. Some ER stress genes (HSPA5, CALR) peripheral. Core program is RNA processing/splicing.
Genes
AFF4, ARL6IP1, CALR, CCNL1, CLK1, DDX3X, DDX5, EIF4A2, HSPA5, NUFIP2, PCF11, RBM39, RSRP1, SRSF5, TAF1D, ZFP36L1
Most correlated modules
- ATF4 Stress Response · correlation 0.89
- Chromatin Modification · correlation 0.82
- Integrated Stress Response · correlation 0.81
- Antiviral Restriction · correlation 0.80
- NF-kB signaling · correlation 0.74
- B-cell signaling regulators · correlation 0.73
- Heat Shock Response · correlation 0.72
- Chromatin Regulation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.