Chromatin Modification
Gene co-expression module in CD19⁺ B cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes are chromatin/transcriptional regulators (KMT2E, PRDM2, JMJD1C, EPC1 histone methyltransferases/demethylases and chromatin modifiers), splicing factor SF1, and signaling adaptors (STK4/MST1, AKAP13, CREBRF). The module is dominated by chromatin-modifying enzymes and transcriptional regulators with uniform low expression, suggesting a generic nuclear regulatory program. KMT2E, PRDM2, JMJD1C, EPC1 are clearest concordant members for chromatin regulation. STK4 is a Hippo kinase important in lymphocyte homeostasis. Mixed but anchored on chromatin/transcription machinery.
Genes
AKAP13, CREBRF, EPC1, GCC2, GPBP1, JMJD1C, KMT2E, OFD1, PPP1R2, PRDM2, RAB11FIP1, SERINC1, SF1, STK4, VAMP2
Most correlated modules
- Leukocyte Migration Signaling · correlation 0.88
- NF-kB signaling · correlation 0.86
- BCR Signaling Regulation · correlation 0.84
- B-cell signaling regulators · correlation 0.83
- mRNA Splicing · correlation 0.82
- Chromatin Regulation · correlation 0.81
- Chromatin modifiers · correlation 0.77
- Antiviral Restriction · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.