ATF4 Stress Response
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
ATF4 hub with INSIG1, HMGCS1 (sterol synthesis), ERO1B (ER oxidative folding), ZFAND5, KLF10, plus FUS. ATF4-driven integrated stress response coupled to lipid/sterol metabolism and ER. Neighbor of M82 ISR and M47 HSP modules. Represents ATF4/ISR-ER stress program.
Genes
ATF4, BRD2, CCNYL1, ERO1B, FUS, GLA, HMGCS1, INSIG1, KLF10, NEU1, YME1L1, ZFAND5
Most correlated modules
- mRNA Splicing · correlation 0.89
- Integrated Stress Response · correlation 0.84
- Immediate early response · correlation 0.81
- Immediate Early NFkB · correlation 0.79
- NF-kB signaling · correlation 0.72
- Antiviral Restriction · correlation 0.72
- Heat Shock Response · correlation 0.71
- Early Response Stress · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.