TGF-beta/differentiation
Gene co-expression module in CD19⁺ B cells
| Category | Intercellular communication |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
Mixed small module with hubs SLC12A6, LYST, KLF3, ST3GAL1, SMAD3, CDC42SE1. SMAD3 (TGF-beta signaling), KLF3 (transcriptional regulator of B cell development), ST3GAL1 (sialylation), CDC42SE1 (cytoskeletal). The combination of SMAD3/TGF-beta signaling and B-cell differentiation regulators in inflamed tissue suggests a TGF-beta-linked differentiation program, though heterogeneous.
Genes
CDC42SE1, CEMIP2, ENC1, KLF3, LYST, SLC12A6, SMAD3, ST3GAL1, TSPAN3
Most correlated modules
- NFkB/MAPK activation · correlation 0.77
- Naive B cell · correlation 0.74
- MHC-II antigen presentation · correlation 0.70
- Antiviral Restriction · correlation 0.69
- Notch signaling · correlation 0.69
- Hypoxia/metabolic stress · correlation 0.64
- B cell activation signaling · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.