B Cell Identity Signaling
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Top hub LYN is the key SRC-family kinase in BCR signaling, with RHOH (lymphocyte signaling), PAX5 (master B-cell transcription factor), ELF1, ST8SIA4 (sialyltransferase), UGCG. PAX5 and LYN are core B-cell identity/maturation genes; this module reflects a B-cell identity/BCR signaling program. Coherent core module anchored on LYN and PAX5.
Genes
ARID4B, ELF1, LYN, PAX5, RHOH, ST8SIA4, TMEM131, UGCG
Most correlated modules
- B-cell signaling regulators · correlation 0.88
- Chromatin modifiers · correlation 0.85
- MHC-II antigen presentation · correlation 0.82
- BCR Signaling Regulation · correlation 0.82
- B-cell activation · correlation 0.80
- B-cell signaling regulators · correlation 0.78
- Leukocyte Migration Signaling · correlation 0.78
- Chromatin Modification · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.