PRR7 — Proline rich 7, synaptic
PRR7 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRR7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Notch signaling Intercellular communication | ARL4D, ARRDC2, HES1, ICOSLG, IRS2, KLF4, MXI1, NRARP +2 more | View in SCUBA |
| CD4⁺ T cells | Unfolded Protein Response Protein processing & ER | ARF4, ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3 +7 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more | |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | BMP/TGF-β Inhibitory Immune regulation | ACHE, BUD31, FAM43A, ID1, LMNA, N4BP3, RGS16, SMAD7 +2 more |
About the gene
| Synonyms | MGC10772 |
|---|---|
| Chromosome | 5: 177446445-177456286 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Adaptive immunity, Immunity |
Function
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.