SERF2 — Small EDRK-rich factor 2

SERF2 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SERF2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ARHGDIB, ARPC3, ATP5MG, CAPNS1, GMFG, IFI27L2, OAZ1, TAF10 +1 more	View in SCUBA
CD4⁺ T cells	Actin cytoskeleton Cytoskeletal	ACTB, ACTG1, ARPC2, ARPC3, CLIC1, COPE, ELOB, GAPDH +3 more	View in SCUBA
CD8⁺ T cells	Actin Cytoskeleton Cytoskeletal	ACTB, ARF6, ARPC1B, ARPC4, BRK1, CAPZB, CFL1, CORO1A +10 more	View in SCUBA
Endothelial	Mitochondrial OxPhos Mitochondrial & OxPhos	ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, PFN1, POLR2E +3 more	View in SCUBA
Enterocytes	Abundant Transcript Baseline Housekeeping	ATP5IF1, C15orf48, CALM2, CHCHD2, CSTB, GHITM, KRT8, LGALS3 +6 more	View in SCUBA
Fibroblasts	Mitochondrial OXPHOS Mitochondrial & OxPhos	ATP5F1E, ATP5MG, ATP5PO, COX4I1, GNG5, PSMB3, UQCR11, UQCRB +1 more	View in SCUBA
Gamma-delta T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B +12 more
Glial cells	Proteasomal Proteostasis Protein processing & ER	CD63, CLIC1, COX7A2, ELOB, MYL12B, PDIA6, PSMA7, PSMB1 +3 more	View in SCUBA
Goblet cells	ER Chaperone Glycosylation Protein processing & ER	ANG, ATP6V1G1, CD63, FKBP2, NANS, OST4, PPIC, RABAC1 +4 more	View in SCUBA
Innate lymphoid cells	Actin Cytoskeleton Remodeling Cytoskeleton & motility	APRT, ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2 +17 more	View in SCUBA
Lymphatic endothelial	Actomyosin Cytoskeleton Cytoskeletal	BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1 +8 more	View in SCUBA
Macrophages	Mitochondrial OXPHOS Mitochondrial & OxPhos	APRT, ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB +28 more	View in SCUBA
Mucosal-associated invariant T cell	NADPH Oxidase & Innate Immune Inflammation	ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, GNG5, HIGD2A +9 more
Smooth muscle cells	Translation elongation housekeeping Housekeeping	COX4I1, EEF1A1, EEF1D, EEF2, FTH1, FTL, GAPDH, PTMA +4 more	View in SCUBA

About the gene

Synonyms	4F5REL, FAM2C, H4F5rel, HsT17089
Chromosome	15: 43777087-43804427
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.