TBCA — Tubulin folding cofactor A
TBCA belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBCA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin Cytoskeleton Cytoskeletal | ARHGDIB, ARPC3, ATP5MG, CAPNS1, GMFG, IFI27L2, OAZ1, SERF2 +1 more | View in SCUBA |
| Endothelial | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1D, ATP5MC2, ATP5PO, COX7C, ERP29, HIGD2A, HINT1, IMPDH2 +10 more | View in SCUBA |
| Gamma-delta T cells | Protein Homeostasis Chaperones Housekeeping | ATXN10, DYNLRB1, GMFG, HIGD1A, NAA10, POLR2J, PPIA, PPIB +6 more | |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5MF, H2AZ1, H4C3, INO80E, LYPLA2, NDUFA3, NDUFB1, SEM1 +3 more | |
| Smooth muscle cells | Post-translational regulators Housekeeping | ANXA11, BAG1, BANF1, CALM3, CAMTA1, ERH, HMGN3, MYO1C +6 more | View in SCUBA |
About the gene
| Chromosome | 5: 77691166-77868780 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Tubulin-folding protein; involved in the early step of the tubulin folding pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.