Immune regulation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes SLFN12L, SLFN13 (schlafen family, interferon/proliferation regulated), NLRC3 (negative regulator of innate immune/inflammatory signaling), FAM111A, and TET1 (DNA demethylation). Moderate coherence with several weak-membership hubs. The schlafen genes and NLRC3 suggest an immune regulatory / interferon-influenced program, but the mix is heterogeneous. Positive inflammation correlation. Best fit is immune regulation given NLRC3 and schlafens.
Genes
DENND1B, FAM111A, GIT2, GOLGA8A, LPIN1, NLRC3, PPP2R5C, PSD4, RUFY3, SLFN12L, SLFN13, TET1, TMEM116, UTRN
Most correlated modules
- Inflammatory activation · correlation 0.72
- Th17 lineage · correlation 0.70
- Rho-GTPase Migration · correlation 0.70
- Interferon response · correlation 0.69
- T cell co-receptors · correlation 0.68
- Gamma-delta T cell · correlation 0.66
- DNA repair/replication · correlation 0.65
- Th17 effector · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.