DNA repair/replication
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are DNA-repair and chromatin/centrosome related: HELB (DNA helicase B, replication/repair), HAUS3 (augmin spindle complex), KMT2C (histone methyltransferase), CKAP2 (mitotic microtubule), REV3L (translesion DNA polymerase zeta), EPM2AIP1 (MLH1-interacting, mismatch repair), FOXO3, OFD1 (centriole). The spindle/centrosome (HAUS3, CKAP2, OFD1) plus DNA repair (HELB, REV3L, EPM2AIP1) genes suggest a genome maintenance / proliferation-related program. Mixed coherence. Best fit is DNA/chromatin regulation.
Genes
ACAP2, BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB, KMT2C, MIA3, OFD1, PPM1K, REV3L
Most correlated modules
- Post-transcriptional regulation · correlation 0.70
- Inflammatory effector · correlation 0.70
- Transcription/RNA processing · correlation 0.69
- Interferon response · correlation 0.66
- Immune regulation · correlation 0.65
- Glucocorticoid Immunoregulation · correlation 0.56
- Heat-shock response · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.