Rho-GTPase Migration
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PREX1, ARHGEF7, ARHGAP18, FNBP1, LPXN are Rho/Rac GEF/GAP and cytoskeletal regulators driving actin dynamics and cell motility. RORA and RUNX1 are transcription factors linked to T cell differentiation (RORA toward Th17/ILC programs, RUNX1 broad T cell), and MAP4K1 (HPK1) is a TCR-proximal kinase. The dominant signature of GEF/GAP-mediated migration/adhesion machinery (PREX1, ARHGEF7, ARHGAP18, LPXN paxillin-like, FNBP1) suggests a cell migration/adhesion program, which fits the inflammation-associated upregulation. Uniform expression argues against contamination.
Genes
ARHGAP18, ARHGEF7, FNBP1, HELZ, LPXN, MAP4K1, MIS18BP1, PREX1, RORA, RUNX1, TESC, TMED8, ZFYVE28
Most correlated modules
- Th17 lineage · correlation 0.83
- Inflammatory activation · correlation 0.82
- Th17 effector · correlation 0.82
- Integrin Rap1 Signaling · correlation 0.81
- Actomyosin signaling · correlation 0.80
- Interferon-stimulated genes · correlation 0.77
- TCR Complex Activation · correlation 0.77
- TCR Activation Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.