ER-Golgi Trafficking
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by vesicular trafficking and ER/Golgi processing factors: RAB8A (vesicle transport), RNF167 and RNF146 (E3 ubiquitin ligases), CNIH4 (cargo export), KDELR1 (ER retrieval receptor), ORMDL2 (ER sphingolipid regulation), ALG5 (N-glycosylation). WAS and RASAL3 are immune/cytoskeletal regulators and PYCARD is inflammasome-related, but the dominant coherent theme is intracellular protein/membrane trafficking through the ER-Golgi-endosome system. Uniform expression, no contamination. Best fit is protein processing/ER secretory machinery.
Genes
ALG5, CNIH4, HDDC3, KDELR1, ORMDL2, PYCARD, RAB8A, RASAL3, RBM42, RNF146, RNF167, SSRP1, WAS
Most correlated modules
- Cellular biosynthesis · correlation 0.89
- Vesicle trafficking · correlation 0.88
- NF-kB regulation · correlation 0.82
- Membrane trafficking · correlation 0.77
- Proteasome/translation · correlation 0.76
- T-cell activation · correlation 0.71
- T cell Coinhibition · correlation 0.67
- DNA damage response · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.